Asymptomatic disease

in Lower Extremity Arterial Disease

Applied

Type

Reinforcement

Confidence

90%

Created

Mar 19, 2026

Evidence

2 sources

Rationale

The section was updated to include the latest epidemiological data from the 2025 AHA report and to reflect the growing importance of subclinical atherosclerosis assessment as highlighted in recent meta-analyses. Abbreviations (ABI, CV) were expanded on first use per instructions.

Evidence

Garg PK et al. Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies. Arterioscler Thromb Vasc Biol. 2023. PMID: 38150519.
Verified source
PubMedDOI
Martin SS et al. 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. Circulation. 2025. PMID: 39866113.

The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

Verified source
PubMedDOI

Content Changes

* Detected by an abnormal ankle-brachial index (ABI) (<0.9).[@aboyans2012] Assessment of subclinical atherosclerosis in asymptomatic populations is increasingly recognized as a critical tool for cardiovascular risk stratification [@garg2023].
* Still associatedAssociated with high systemic CVcardiovascular risk.[@hiatt2015](CV) risk and a substantial global health burden [@hiatt2015][@martin2025].
Go to section in textbookDispute / Submit evidenceAll updates