Buerger disease (Thromboangiitis obliterans) in upper extremity disease
Applied
Type
ModificationConfidence
85%
Created
Mar 19, 2026
Evidence
1 source
Rationale
The original text suggested revascularization was rarely feasible. Recent meta-analysis evidence (Galyfos et al., 2022) demonstrates that endovascular angioplasty is a viable and effective option for TAO patients presenting with limb-threatening ischemia. The text was updated to include this modality while maintaining the importance of smoking cessation and medical management. Abbreviations for thromboangiitis obliterans (TAO) and chronic limb-threatening ischemia (CLTI) were expanded on first use.
Evidence
Content Changes
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Buerger disease, also known as thromboangiitis obliterans,obliterans (TAO), is an inflammatory vaso-occlusive disorder that predominantly affects young tobacco users. The disease is characterized by distal, segmental arterial occlusions and frequently associated superficial thrombophlebitis. Upper extremity involvement occurs in a substantial proportion of affected patients, manifesting as digital ischemia and tissue loss. Diagnosis relies on clinical criteria (young smoker, distal ischemia, exclusion of autoimmune diseases) and angiographic findings of corkscrew collaterals. Management mandates absolute smoking cessation, as no other therapy prevents progression. RevascularizationWhile revascularization is rarelyoften feasiblechallenging due to the distal nature of the disease, thoughendovascular sympathectomyangioplasty has emerged as a feasible option for patients with chronic limb-threatening ischemia (CLTI), showing reasonable early and late outcomes in systematic reviews [@galyfos2022]. Sympathectomy or iloprost may also provide symptomatic relief in select cases [@olin2000].