Asymptomatic disease

in Lower Extremity Arterial Disease

Applied

Type

Modification

Confidence

92%

Created

Mar 26, 2026

Evidence

2 sources

Rationale

The section was updated to include the most recent epidemiological data from the 2025 AHA statistics report and a 2023 meta-analysis on subclinical atherosclerosis. Abbreviations were expanded on first use as per instructions. The core structure was preserved while enhancing the clinical context of asymptomatic PAD.

Evidence

Garg PK et al. Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies. Arterioscler Thromb Vasc Biol. 2023. PMID: 38150519.
Verified source
PubMedDOI
Martin SS et al. 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. Circulation. 2025. PMID: 39866113.
Verified source
PubMedDOI

Content Changes

* Detected by an abnormal ankle-brachial index (ABI) (<0.9).[@aboyans2012](<0.90) in individuals without exertional leg symptoms [@aboyans2012][@garg2023-assessment].
* StillAsymptomatic peripheral artery disease (PAD) is associated with a high risk of systemic CVcardiovascular risk.[@hiatt2015](CV) events and mortality [@hiatt2015][@martin2025-martin].
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