Thrombosis

in Overview of Vascular Disease

Applied

Type

Addition

Confidence

95%

Created

Mar 27, 2026

Evidence

1 source

Rationale

The section was updated to include atrial fibrillation (AF) as a critical clinical context for arterial thromboembolism, as highlighted by the 2023 ACC/AHA guideline. Abbreviations for pulmonary embolism (PE) and atrial fibrillation (AF) were expanded on first use according to the style guide.

Evidence

Joglar JA, et al. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2023. PMID: 38033089.
Verified source
PubMedDOI

Content Changes

Arterial thrombosis is platelet-driven, while venous thrombosis is fibrin-rich. Both involve the coagulation cascade and interplay between clotting factors and endothelium. Pulmonary embolism (PE) arises from embolization of venous thrombi [@rutherford2018-rutherford]. Additionally, atrial fibrillation (AF) is a significant source of cardioembolic arterial events, often resulting from thrombus formation in the left atrial appendage due to blood stasis [@aha2023-joglar].
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